Sherburn Hospital (also known as Christ's Hospital in Sherburn) is a medieval hospital located in the hamlet of Sherburn House to the south-east of Durham, England.

The hospital was founded in 1181 by Bishop Pudsey to care for 65 lepers and dedicated to "our Lord, to the Blessed Virgin, to St. Lazarus and his sisters, Mary and Martha". Its statutes were amended by Bishop Kellaw and later by Bishop Langley.

The hospital was endowed with a range of lands, including Sherburn, Garmondsway Moor, Ebchester, Whitton, Raceby, and Sheraton and his mill on Sherburnhouse Beck.

The hospital, as the Sherburn House Charity now provides residential care and sheltered housing for residents and former residents of the diocese of Durham, and is a significant grant making body to local groups to 'relieve need, hardship and distress in the north-east of England'.